Top Salts
Pyrazinamide
How Pyrazinamide works
Pyrazinamide is an antibiotic. It works by slowing the growth of bacteria that causes tuberculosis.
Side Effects
Jaundice, Hepatitis (viral infection of liver), Increased liver enzymes, Joint pain
Usage
Pyrazinamide is used in the treatment of tuberculosis.
Frequently Asked Questions
Q. What is Pyrazinamide and what is it used for?Pyrazinamide is an antibiotic. It is used in combination with other antibiotics in the treatment of tuberculosis
Q. Is Pyrazinamide bactericidal?Pyrazinamide is both a bacteriostatic and a bactericidal antibiotic. It stops the growth of bacteria (bacteriostatic) in certain cases and kills (bactericidal) the tuberculosis causing bacteria in other cases
Q. How does Pyrazinamide work/treat tuberculosis?Pyrazinamide kills or stops growth of bacteria that causes tuberculosis (Mycobacterium tuberculosis). The exact mechanism of action for Pyrazinamide is not known
Q. How does Pyrazinamide cause hyperuricemia and gout?Following oral intake of Pyrazinamide, it gets converted in the body to pyrazinoic acid (active chemical form of Pyrazinamide). Pyrazinoic acid blocks the excretion of urates (salt form of uric acid) by the kidneys. This causes an increase in blood levels of uric acid (hyperuricemia). Excess uric acid accumulation between joints causes pain, swelling, redness and stiffness in joints (gout).
