How Rabeprazole works

Rabeprazole is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in relief of acid-related indigestion and heartburn.

Side Effects

Nausea, Headache, Abdominal pain, Constipation, Flatulence, Diarrhoea

Usage

Rabeprazole is used in the treatment of acidity, heartburn, intestinal ulcers and stomach ulcers.

Frequently Asked Questions

Q. Is Rabeprazole an over the counter product?

No, Rabeprazole is not an over the counter product, it is available when prescribed by a doctor.

Q. Is Rabeprazole an antacid?

Rabeprazole is not an antacid. It belongs to the class of proton pump inhibitors (PPIs) which decrease the amount of acid produced in the stomach while antacids only neutralize the stomach acid by coating the stomach.

Q. Does Rabeprazole cause osteoporosis (thinning of bones)?

Yes, long term use of Rabeprazole can cause osteoporosis (thinning of bones). It decreases the calcium absorption leading to calcium deficiency and increases the risk of bone fractures of hip, wrist or spine. Inform your doctor if you have osteoporosis or if you are taking corticosteroids (these can increase the risk of osteoporosis) before starting your therapy. Take enough calcium and vitamin D to reduce the risk.

Q. Can I take aluminum hydroxide and magnesium carbonate or other antacids with Rabeprazole?

Rabeprazole can be taken with antacids like aluminum hydroxide, magnesium carbonate or sodium bicarbonate. Rabeprazole takes a few days to show its effect, so antacids can be taken during that time for relief of acidity and heartburn. However, antacids should be taken two hours before or one hour after taking Rabeprazole as antacids can increase the pH of the stomach and decrease the action of Rabeprazole which requires a lower pH for its action.

Q. Does Rabeprazole have addictive potential?

No, Rabeprazole has no addictive potential. It shows no withdrawal symptoms when you stop using this medicine.

Q. Is Rabeprazole safe?

Yes, Rabeprazole is safe if taken for prescribed duration in prescribed doses as advised by your doctor. However, there are some very common side effects that you can experience at effective doses like nausea, abdominal pain, constipation, diarrhea, and flatulence.

Q. Does Rabeprazole cause hair loss?

No, hair loss has not been reported as a side effect of Rabeprazole. Talk to your doctor in case there is excessive hair fall as it could be due to some underlying problem that needs attention.

Q. Does Rabeprazole cause flatulence (gas or bloating)?

Flatulence (gas) has been reported as a common side effect of Rabeprazole. Although it would be mild to moderate in nature and transient.

Q. Does Rabeprazole cause tinnitus (ringing in the ears)?

Tinnitus (ringing sensation in the ears) has not been seen as a side effect with the use of Rabeprazole. Talk to your doctor in case you have this problem as it could be due to some underlying condition that needs attention.

Q. Does Rabeprazole cause weight gain?

Weight gain has been reported as a rare side effect of Rabeprazole. Weight gain can add to your problem of acidity and heartburn. So, you must try to do some exercise and make healthy changes in your diet to control your weight.

Q. Does Rabeprazole expire?

Yes, like any other medicine, Rabeprazole also expires. Always check the expiry date on the pack of the medicine before using it.

Q. Does Rabeprazole cause constipation?

Constipation is a common side effect seen in patients using Rabeprazole. Making healthy lifestyle changes like doing yoga, taking high fiber diet and plenty of fluids will prevent constipation.

Q. Does Rabeprazole cause high blood pressure?

Rabeprazole is not reported to cause high blood pressure. In case you experience high blood pressure, talk to your doctor as it may need attention. Common side effects seen with Rabeprazole includes nausea, abdominal pain, constipation, diarrhea, and flatulence.

Q. Does Rabeprazole cause headache?

Headache is reported as one of the common side effects of Rabeprazole. Please consult your doctor in case you experience an intolerable headache for a prolonged duration while taking Rabeprazole.

Q. Can I take Rabeprazole with ranitidine?

Yes, Rabeprazole can be taken with ranitidine. As Rabeprazole show its effect after some days, Ranitidine can be taken for immediate relief. No drug-drug interactions or change in side effect profile has been reported when they are used together compared to either drug alone.

Q. Can I take Rabeprazole with ibuprofen?

Rabeprazole can be taken with ibuprofen. Rabeprazole is used to prevent painkiller (NSAIDs) induced gastritis and stomach ulcers by decreasing the production of acid in the stomach. There are no reported drug interactions or harmful effects when they are used together.

Q. Can I take Rabeprazole with paracetamol?

Rabeprazole can be taken with paracetamol. Rabeprazole is used to prevent painkiller (NSAIDs) induced stomach ulcers by decreasing the production of acid in the stomach. There are no reported drug interactions or harmful effects when they are used together.

Q. How is Rabeprazole metabolized?

Rabeprazole is metabolized in the liver mainly by microsomal CYP450 enzymes (CYP2C19 and CYP3A4). Patients with poor CYP2C19 enzymatic activity will have higher levels of Rabeprazole for a long time and a better suppression of stomach acid.

Q. Can Rabeprazole be used for the treatment of throat infection?

No, Rabeprazole is not meant for throat infections. However, it may be given along with antibiotics and other drugs to protect the stomach from excessive acid secretion.

Q. Why is Rabeprazole used with cinitapride for some conditions?

Cinitapride increases the movement of the gut and is useful in the treatment of conditions like heartburn, dyspepsia and is also useful in the treatment of reflux esophagitis. It has much better efficacy when it is used with Rabeprazole.

Q. Does Rabeprazole play any role in treating ulcerative colitis?

Rabeprazole does not have any role in the treatment of ulcerative colitis. However, it can be given if there is associated dyspepsia or increased stomach acid secretion. Talk to your doctor before taking any treatment for ulcerative colitis.

Q. Can Rabeprazole be used for reflux esophagitis?

Yes, Rabeprazole is effective in the treatment of reflux esophagitis. It is a disease in which stomach acid or bile irritates and inflames the lining of the food pipe. Rabeprazole decreases the production of acid in the stomach and can help in healing the inflamed and eroded esophagus.The efficacy is better when it is given in combination with a prokinetic agent like domperidone.

Q. Is Rabeprazole being used for treating weight loss?

No, Rabeprazole is not used for the treatment of weight loss. It is a proton pump inhibitor and is used for the treatment of acidity, heartburn, intestinal ulcers and stomach ulcers.

Q. Is there any role of Rabeprazole in treating hiatus hernia?

A hiatus hernia is the bulging of the stomach into the chest through an esophageal opening in the diaphragm which is larger than the normal size. A hiatus hernia is associated with acidity and heartburn. Rabeprazole does not play any role in treating hiatus hernia, however, it can help in relieving the symptoms of acidity, heartburn and acid reflux.

Q. Can I take Rabeprazole with vitamin D?

Yes, vitamin D can be taken with Rabeprazole. Vitamin D is generally advised to be taken as a supplement with Rabeprazole as its long-term use decreases the absorption of calcium and cause calcium deficiency. This can lead to osteoporosis (thinning of bones) and increase the risk of bone fractures like hip, wrist and spine fractures.

Q. How is Rabeprazole useful in the treatment of H. pylori?

Rabeprazole is used along with antibiotics for the treatment of H.Pylori infection. It works by decreasing stomach acid volume and decreasing breakdown and washout of antibiotics leading to an increased antibiotic concentration and tissue penetration. It also helps in the symptomatic relief by decreasing associated acidity, reflux, and heartburn.

Q. Can I take Rabeprazole with domperidone?

Rabeprazole can be safely taken with domperidone as no harmful effects have been reported clinically. A fixed-dose combination of these two medicines is also available. Domperidone increases gut motility and Rabeprazole decreases the acid production in the stomach. So, this combination is very effective in the treatment of reflux esophagitis associated with acidity, heartburn, intestinal and stomach ulcers.

Q. Can long term use of Rabeprazole cause magnesium deficiency?

Long-term use of Rabeprazole can lower magnesium levels in patients taking multiple daily doses for a year or longer (at least 3 months). Get your magnesium levels checked at regular intervals. Tell your doctor if you experience seizures, dizziness, abnormal or fast heartbeat, jitteriness, jerking movements or shaking (tremors), muscle weakness, spasms of the hands and feet, cramps, muscle aches or spasm of the voice box.